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Mst1rFv2-s
Spontaneous Allele Detail
Summary
Symbol: Mst1rFv2-s
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Friend virus susceptibility 2
MGI ID: MGI:1857882
Synonyms: Fv2ss
Gene: Mst1r  Location: Chr9:107784072-107797582 bp, + strand  Genetic Position: Chr9, 59.07 cM, cytoband F1
Alliance: Mst1rFv2-s page
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous
Mutation:    Undefined
 
Mutation detailsThis allele expresses both a normal transcript and a mutant transcript initiating in intron 10 that encodes a truncated form of the receptor that lacks most of the extracellular domain. (J:57881)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mst1r Mutation:  61 strains or lines available
Notes
This virus susceptibility allele is found in strains NIH Swiss, DDD, BALB/c, DBA, AKR, and others. Mouse strains carrying this allele are susceptible to progression of infection by Friend virus. To date the resistance (wild-type) allele has been found only in strains A, C57BL/6 and other members of the C57 and C58 family and in M. spretus. This locus probably also influences susceptibility to Rauscher leukemia virus, and the locus named Rv2 may be the identical.
References
Original:  J:172785 Friend C, Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307-18
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory