Bmp2^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Bmp2^tm1Brd
• Name: bone morphogenetic protein 2; targeted mutation 1, Allan Bradley
• MGI ID: MGI:1857894
• Synonyms: bmp2^m1
• Gene: Bmp2 Location: Chr2:133394079-133404805 bp, + strand Genetic Position: Chr2, 65.21 cM
• Alliance: Bmp2^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36213
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An HPRT mini-gene cassette replaced a 4.0 kb genomic fragment that contains sequences encoding the entire BMP2 mature region and two thirds of the propeptide. (J:36213)

Expression

In Mice Carrying this Mutation:	77 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp2 Mutation: 27 strains or lines available

References

• Original: J:36213 Zhang H, et al., Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996 Oct;122(10):2977-86
• All: 22 reference(s)