Cftr^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Cftr^tm1Bay
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857897
• Synonyms: cftr^m1Bay
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm1Bay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15244
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Cftr^tm1Bay involves 1 genes/genome features (Cftr) View all
• Mutation details: An insertion vector that contained exon 3 and a neomycin selection cassette was inserted into intron 2 of the gene. The duplication of exon 3 caused a frameshift change. (J:15244)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 98 strains or lines available

References

• Original: J:15244 O'Neal WK, et al., A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Hum Mol Genet. 1993 Oct;2(10):1561-9
• All: 2 reference(s)