Nkx3-2^tm1.1Tlu
Targeted Allele Detail

Summary

• Symbol: Nkx3-2^tm1.1Tlu
• Name: NK3 homeobox 2; targeted mutation 1.1, Thomas Lufkin
• MGI ID: MGI:1857926
• Synonyms: Bapx1 -, Bapx1 neo-
• Gene: Nkx3-2 Location: Chr5:41918826-41921563 bp, - strand Genetic Position: Chr5, 22.58 cM
• Alliance: Nkx3-2^tm1.1Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55583
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 1 and most of exon 2, which corresponds to nearly all of the coding region, with a lox-P flanked neomycin cassette. The neomycin cassette was removed via Cre mediated recombination in the final allele. (J:55583)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-2 Mutation: 21 strains or lines available

References

• Original: J:55583 Tribioli C, et al., The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 1999 Dec;126(24):5699-711
• All: 1 reference(s)