Gjb1^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjb1^tm1Kwi
• Name: gap junction protein, beta 1; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:1857927
• Synonyms: Cx32-
• Gene: Gjb1 Location: ChrX:100419984-100429235 bp, + strand Genetic Position: ChrX, 44.06 cM, cytoband D-F4
• Alliance: Gjb1^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36146
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2 of the gene, resulting in a stop codon 90 nucleotides after the translational start and a new start codon 15 base pairs further downstream. Northern blots of total liver RNA from homozygous mutant mice showed no detectable transcript for the gene. (J:36146)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gjb1^tm1Kwi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjb1 Mutation: 27 strains or lines available

References

• Original: J:36146 Nelles E, et al., Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9565-70
• All: 82 reference(s)