Mxi1^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Mxi1^tm1Rdp
• Name: MAX interactor 1, dimerization protein; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:1857929
• Synonyms: mxi1^-
• Gene: Mxi1 Location: Chr19:53298509-53361724 bp, + strand Genetic Position: Chr19, 47.53 cM, cytoband D
• Alliance: Mxi1^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48236
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to eliminate an exon required for the production of two isoforms. Disruption of the locus was confirmed by RT-PCR.

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mxi1^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mxi1 Mutation: 35 strains or lines available

References

• Original: J:48236 Schreiber-Agus N, et al., Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature. 1998 Jun 4;393(6684):483-7
• All: 4 reference(s)