Terc^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Terc^tm1Rdp
• Name: telomerase RNA component; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:1857930
• Synonyms: mTerc^-, mTR-, Terc-, TR-
• Gene: Terc Location: Chr3:96321753-96322149 bp, - strand Genetic Position: Chr3, 41.82 cM, cytoband F/G
• Alliance: Terc^tm1Rdp page

Axial/lateral elements of synaptonemal complexes and apoptosis of seminiferous tubules in Terc^tm1Rdp/Terc^tm1Rdp mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43517
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the entire gene with a neomycin cassette. (J:43517)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Terc^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Terc Mutation: 8 strains or lines available

References

• Original: J:43517 Blasco MA, et al., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997 Oct 3;91(1):25-34
• All: 195 reference(s)