Brca1^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Bhk
• Name: breast cancer 1, early onset; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:1857931
• Synonyms: B1-, Brca1-, Brca1^delta223-763
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31571
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced a 1.5 kb genomic fragment containing exon 11. (J:31571)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Bhk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:31571 Gowen LC, et al., Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996 Feb;12(2):191-4
• All: 12 reference(s)