Pgr^tm1Bwo
Targeted Allele Detail

Summary

• Symbol: Pgr^tm1Bwo
• Name: progesterone receptor; targeted mutation 1, Bert W O'Malley
• MGI ID: MGI:1857933
• Synonyms: PR^-, PRKO
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^tm1Bwo page

Uterine defects in Pgr^tm4.2Lyd/Pgr^tm4.2Lyd and Pgr^tm1Bwo/Pgr^tm1Bwo mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28980
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was inserted into the first exon and downstream from the initiating codons that encode the A and B isoforms to effectively disrupt transcription of both isoforms. Northern analysis indicated a lack of gene specific transcript. Competitive binding assays for the progesterone receptor indicated a lack a functional protein in homozygous mutant animals. (J:28980)

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pgr^tm1Bwo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 75 strains or lines available

References

• Original: J:28980 Lydon JP, et al., Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995 Sep 15;9(18):2266-78
• All: 72 reference(s)