Pten^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Ppp
• Name: phosphatase and tensin homolog; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:1857936
• Synonyms: PTEN-
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49532
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 4 and 5, which contain sequences encoding the phosphatase domain. (J:49532)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:49532 Di Cristofano A, et al., Pten is essential for embryonic development and tumour suppression. Nat Genet. 1998 Aug;19(4):348-55
• All: 61 reference(s)