Pten^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Mak
• Name: phosphatase and tensin homolog; targeted mutation 1, Tak W Mak
• MGI ID: MGI:1857937
• Synonyms: mPTEN-, mPTEN^3-5, Pten-
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Mak page

Embryonic defects in Pten^tm1Mak/Pten+

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50437
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing the splice donor site of exon 2 and exons 3-5. RT-PCR analysis on liver RNA from heterozygous mice demonstrated that an aberrant, smaller transcript was made from this allele, but no functional protein is predicted to be made. (J:50437)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:50437 Suzuki A, et al., High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 1998 Oct 22;8(21):1169-78
• All: 23 reference(s)