Xpa^tm1Hvs
Targeted Allele Detail

Summary

• Symbol: Xpa^tm1Hvs
• Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg
• MGI ID: MGI:1857939
• Synonyms: XPA-, XpaKO
• Gene: Xpa Location: Chr4:46175222-46196317 bp, - strand Genetic Position: Chr4, 24.49 cM, cytoband C2
• Alliance: Xpa^tm1Hvs page

Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Hvs/Xpa^tm1Hvs mice display postnatal growth retardation

Show the 10 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28710
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced exons 3 and 4 of the Xpa gene. No stable intact or truncated XPA transcripts were detected in livers of homozygous mutant animals. (J:28710)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Xpa^tm1Hvs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Xpa Mutation: 21 strains or lines available

References

• Original: J:28710 de Vries A, et al., Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature. 1995 Sep 14;377(6545):169-73
• All: 69 reference(s)