Msh2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Msh2^tm1Mak
• Name: mutS homolog 2; targeted mutation 1, Tak W Mak
• MGI ID: MGI:1857940
• Synonyms: MSH2-
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28397
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette was inserted in an antisense orientation in an exon of the gene that corresponded to exon 11 of the human gene, resulting in the deletion of 68 bp (1959 - 2026). Western blots of protein extracts from tail fibroblasts of homozygous mutant mice showed no detectable protein expressed for the targeted gene. (J:28397)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:28397 Reitmair AH, et al., MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet. 1995 Sep;11(1):64-70
• All: 58 reference(s)