Cdkn2a^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1Rdp
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:1857942
• Synonyms: ARF-, Cdkn2a-, Cdkn2a^lox, ink4a-, INK4a-, Ink4a/arf-, Ink4a/Arf-, INK4a-Arf^-, Ink4a/Arf^KO, Ink4a-Arf-null, Inkdelta2/3 null, p16^INK4a-, p16^INK4a, p16-KO, p16p19^null
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1Rdp page

Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terc^tm1Rdp/Terc^tm1Rdp and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53805
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16^Ink4a and p19^ARF alternative splice transcripts are mutated in this allele. (J:53805)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: human supratentorial ependymoma subgroup in homozygous mice (J:163931)

References

• Original: J:53805 Serrano M, et al., Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27-37
• All: 348 reference(s)