Cdh3^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Cdh3^tm1Hyn
• Name: cadherin 3; targeted mutation 1, Richard Hynes
• MGI ID: MGI:1857943
• Synonyms: E-cadherin^-
• Gene: Cdh3 Location: Chr8:107237484-107283543 bp, + strand Genetic Position: Chr8, 53.16 cM
• Alliance: Cdh3^tm1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44359
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin phosphotransferase expression cassette was inserted into a unique XhoI site in exon 11. Western analysis of placental lysates from intercross progeny did not detect expression of the protein in homozygous mice. (J:44359)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdh3^tm1Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh3 Mutation: 51 strains or lines available

References

• Original: J:44359 Radice GL, et al., Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol. 1997 Nov 17;139(4):1025-32
• All: 8 reference(s)