Mdm2^tm1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm1Glo
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1, Guillermina Lozano
• MGI ID: MGI:1857945
• Synonyms: Mdm2^-
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29810
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced two-thirds of the protein-coding sequences of the gene, including the acidic and zinc-finger domains, from amino acids 221-489. (J:29810)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:29810 Montes de Oca Luna R, et al., Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995 Nov 9;378(6553):203-6
• All: 45 reference(s)