Pms2^tm1Lisk
Targeted Allele Detail

Summary

• Symbol: Pms2^tm1Lisk
• Name: PMS1 homolog2, mismatch repair system component; targeted mutation 1, Michael Liskay
• MGI ID: MGI:1857947
• Synonyms: Pms2^-
• Gene: Pms2 Location: Chr5:143846782-143870786 bp, + strand Genetic Position: Chr5, 82.82 cM, cytoband G2
• Alliance: Pms2^tm1Lisk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27389
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was inserted into exon 2, replacing a highly conserved region of the gene. Protein was not detectable by Western analysis in fibroblast cultures from homozygous mutant animals. (J:27389)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pms2^tm1Lisk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pms2 Mutation: 53 strains or lines available

References

• Original: J:27389 Baker SM, et al., Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 1995 Jul 28;82(2):309-19
• All: 39 reference(s)