Tcirg1^tm1Ypl
Targeted Allele Detail

Summary

• Symbol: Tcirg1^tm1Ypl
• Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Yi Ping Li
• MGI ID: MGI:1857950
• Synonyms: Atp6i^-
• Gene: Tcirg1 Location: Chr19:3946050-3957133 bp, - strand Genetic Position: Chr19, 3.62 cM
• Alliance: Tcirg1^tm1Ypl page

Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} and Tcirg1^tm1Ypl/Tcirg1^tm1Ypl mice show osteopetrorickets

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58795
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin resistance cassette replaced 3.0kb of sequence including exons 2-5. (J:58795)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcirg1 Mutation: 36 strains or lines available

References

• Original: J:58795 Li YP, et al., Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999 Dec;23(4):447-51
• All: 4 reference(s)