Bmp1^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Bmp1^tm1Blh
• Name: bone morphogenetic protein 1; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:1857952
• Synonyms: Bmp1^tm1
• Gene: Bmp1 Location: Chr14:70711998-70757674 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Bmp1^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36830
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons encoding amino acids 150-249, disrupting the active site of the astacin-like protease domain common to all splice variants. (J:36830)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp1 Mutation: 47 strains or lines available

References

• Original: J:36830 Suzuki N, et al., Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. Development. 1996 Nov;122(11):3587-95
• All: 5 reference(s)