Bmp8a^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Bmp8a^tm1Blh
• Name: bone morphogenetic protein 8a; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:1857953
• Synonyms: Bmp8a-, Bmp8a^tm1
• Gene: Bmp8a Location: Chr4:123206438-123237045 bp, - strand Genetic Position: Chr4, 57.42 cM
• Alliance: Bmp8a^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46927
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 8 kb genomic fragment containing exons 4-6 was replaced with a neomycin selection cassette. In situ hybridization experiments on spermatids in testes of homozygous male mice demonstrated that an aberrant transcript is produced from this allele, but no functional protein is predicted to be produced from this allele since the majority of the coding sequences were deleted. (J:46927)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp8a Mutation: 19 strains or lines available

References

• Original: J:46927 Zhao GQ, et al., Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Development. 1998 Mar;125(6):1103-12
• All: 3 reference(s)