Apex1^tm1Cur
Targeted Allele Detail

Summary

• Symbol: Apex1^tm1Cur
• Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1, Tom Curran
• MGI ID: MGI:1857956
• Synonyms: ref-1 -
• Gene: Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
• Alliance: Apex1^tm1Cur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34891
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 1-4 was replaced with a neomycin (NEO) cassette driven by phosphoglycerate kinase (PGK) promoter. (J:34891)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apex1 Mutation: 16 strains or lines available

References

• Original: J:34891 Xanthoudakis S, et al., The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23
• All: 5 reference(s)