Apc^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Mmt
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:1857957
• Synonyms: Apc^d716, Apc^delta716, Min^Apcdelta716
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Mmt page

Nascent intestinal polyps in Apc^tm1Mmt/Apc⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25200
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 15 at nucleotide 2150. This mutation is predicted to cause premature truncation of the protein at codon 716. (J:25200)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1Mmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:25200 Oshima M, et al., Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4482-6
• All: 57 reference(s)