Pnliprp2^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Pnliprp2^tm1Gru
• Name: pancreatic lipase-related protein 2; targeted mutation 1, Michael J Grusby
• MGI ID: MGI:1857970
• Synonyms: PLRP2^-, Pnliprp2^tm1Lowe
• Gene: Pnliprp2 Location: Chr19:58748155-58765966 bp, + strand Genetic Position: Chr19, 54.5 cM, cytoband D3
• Alliance: Pnliprp2^tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51627
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by the introduction of a lacZ-neo cassette into the fourth exon via homologous recombination. Immunohistochemistry of acinar cells from pancreas of homozygous mutant animals did not detect protein product, and was positive for beta-galactosidase activity. RNase protection assay detected faint transcript (5% of wild-type signal) in adult homozygous mutant animals thought to be a chimeric transcript incorporating the lacZneo sequence. (J:51627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnliprp2 Mutation: 30 strains or lines available

References

• Original: J:51627 Lowe ME, et al., Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998 Nov 20;273(47):31215-21
• All: 4 reference(s)