Zp3^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Zp3^tm1Dean
• Name: zona pellucida glycoprotein 3; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:1857971
• Synonyms: Zp3^tm1Tra
• Gene: Zp3 Location: Chr5:136008959-136017478 bp, + strand Genetic Position: Chr5, 75.62 cM
• Alliance: Zp3^tm1Dean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36772
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 1. In situ hybridization experiments demonstrated an absence of mRNA in oocytes and the protein was undetectable in immunofluorescence experiments on mutant ovaries and oocytes. (J:36772)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zp3 Mutation: 40 strains or lines available

References

• Original: J:36772 Rankin T, et al., Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development. 1996 Sep;122(9):2903-10
• All: 8 reference(s)