Myf5^tm1Pas
Targeted Allele Detail

Summary

• Symbol: Myf5^tm1Pas
• Name: myogenic factor 5; targeted mutation 1, Institut Pasteur
• MGI ID: MGI:1857973
• Synonyms: myf-5^a2, Myf5^lacZ, myf-5/nlacZ, Myf5-nlacZ
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^tm1Pas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36716
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An nLacZ gene is fused in-frame to the DNA sequences encoding the first 13 amino acids, resulting in a disruption of the gene and expression of nLacZ under the transcriptional regulation of the endogenous promoter. A neomycin resistance cassette, RNA polymerase II promoter and 3' sequence of the HPRT gene were introduced after the reporter gene. (J:36716, J:39308, J:92799)

Expression

In Mice Carrying this Mutation:	209 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:36716 Tajbakhsh S, et al., Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature. 1996 Nov 21;384(6606):266-70
• All: 39 reference(s)