Lbp^tm1Jack
Targeted Allele Detail

Summary

• Symbol: Lbp^tm1Jack
• Name: lipopolysaccharide binding protein; targeted mutation 1, Robert S Jack
• MGI ID: MGI:1857976
• Synonyms: LBP -, Lbp^tm1Csc
• Gene: Lbp Location: Chr2:158148413-158174772 bp, + strand Genetic Position: Chr2, 78.72 cM
• Alliance: Lbp^tm1Jack page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43514
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into an exon encoding alanine 43 to serine 55. No LBP activity was detectable by ELISA assay in serum derived from homozygous mice. (J:43514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lbp Mutation: 30 strains or lines available

References

• Original: J:43514 Jack RS, et al., Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature. 1997 Oct 16;389(6652):742-5
• All: 6 reference(s)