Cd14^tm1Smg
Targeted Allele Detail

Summary

• Symbol: Cd14^tm1Smg
• Name: CD14 antigen; targeted mutation 1, Sanna M Goyert
• MGI ID: MGI:1857977
• Synonyms: CD14^-
• Gene: Cd14 Location: Chr18:36858120-36859851 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Cd14^tm1Smg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32729
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 272 bp genomic segment containing exon 1 and part of exon 2, including the initiation codon, was replaced with a neomycin resistance gene. Flow cytometry experiments on peritoneal macrophages derived from homozygous mice confirmed that no stable protein was made from this allele. (J:32729)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd14 Mutation: 22 strains or lines available

References

• Original: J:32729 Haziot A, et al., Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996 Apr;4(4):407-14
• All: 27 reference(s)