Soat1^tm1Far
Targeted Allele Detail

Summary

• Symbol: Soat1^tm1Far
• Name: sterol O-acyltransferase 1; targeted mutation 1, Bob Farese
• MGI ID: MGI:1857978
• Synonyms: Acact-, Acat-1-
• Gene: Soat1 Location: Chr1:156255678-156301898 bp, - strand Genetic Position: Chr1, 67.71 cM
• Alliance: Soat1^tm1Far page

Adrenal lipid depletion in Soat1^tm1Far/Soat1^tm1Far mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37049
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into a 5' early exon (amino acids 50-100). Reduced levels of a truncated mRNA transcript were detected by Northern blot on RNA from preputial glands. No protein was detected by immunoblot analysis in homogenates from preputial glands, ovaries and adrenals. (J:37049)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Soat1 Mutation: 42 strains or lines available

References

• Original: J:37049 Meiner VL, et al., Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14041-6
• All: 27 reference(s)