Cp^tm1Hrs
Targeted Allele Detail

Summary

• Symbol: Cp^tm1Hrs
• Name: ceruloplasmin; targeted mutation 1, Z Leah Harris
• MGI ID: MGI:1857981
• Synonyms: Cp-, CpKO
• Gene: Cp Location: Chr3:20011218-20063309 bp, + strand Genetic Position: Chr3, 6.1 cM, cytoband D
• Alliance: Cp^tm1Hrs page

Increase in storage iron content in Cp^tm1Hrs/Cp^tm1Hrs liver and spleen

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57730
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing part of exon 17, intron 17 and part of exon 18, which include sequences encoding the residues essential for the formation of the trinuclear copper cluster of the encoded protein. Western blot analysis on serum derived from homozygous mice demonstrated that no detectable encoded protein was present, and activity assays on serum of homozygous mice confirmed that no functional protein is made from this allele. (J:57730)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cp^tm1Hrs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cp Mutation: 76 strains or lines available

References

• Original: J:57730 Harris ZL, et al., Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10812-7
• All: 30 reference(s)