Thbd^tm1Rdr
Targeted Allele Detail

Summary

• Symbol: Thbd^tm1Rdr
• Name: thrombomodulin; targeted mutation 1, Robert D Rosenberg
• MGI ID: MGI:1857983
• Synonyms: TM -
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm1Rdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22630
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced all of the coding sequences of the gene. Transcript and protein levels were found to be reduced by approximately half in heterozygous mutant mice by RNAse protection and Western blot analysis. (J:22630, J:29018, J:42307)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:22630 Healy AM, et al., Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):850-4
• All: 6 reference(s)