Grm7^tm1Nak
Targeted Allele Detail

Summary

• Symbol: Grm7^tm1Nak
• Name: glutamate receptor, metabotropic 7; targeted mutation 1, Shigetada Nakanishi
• MGI ID: MGI:1857984
• Synonyms: Grm7^tmNovartis, mGluR7^-, mGluR7 KO
• Gene: Grm7 Location: Chr6:110622542-111544191 bp, + strand Genetic Position: Chr6, 51.19 cM
• Alliance: Grm7^tm1Nak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52411
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a part of the first coding exon comprising the 5' untranslated region and the first 164 amino acids of the protein. In situ hybridization of sagittal and coronal sections of the brain using an antisense probe corresponding to the first coding exon of the targeted gene showed no detectable mRNA expression in homozygous mutant mice. (J:52411)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm7 Mutation: 125 strains or lines available

References

• Original: J:52411 Masugi M, et al., Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci. 1999 Feb 1;19(3):955-63
• All: 12 reference(s)