Grm6^tm1Nak
Targeted Allele Detail

Summary

• Symbol: Grm6^tm1Nak
• Name: glutamate receptor, metabotropic 6; targeted mutation 1, Shigetada Nakanishi
• MGI ID: MGI:1857985
• Synonyms: mGluR6^-
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^tm1Nak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48532
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.2 kb of sequence encoding part of the transmembrane region. Northern blot analysis did not detect transcript in retina from homozygous mutant mice. (J:48532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 53 strains or lines available

References

• Original: J:48532 Masu M, et al., Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 1995 Mar 10;80(5):757-65
• All: 21 reference(s)