Grm1^tm1Crpl
Targeted Allele Detail

Summary

• Symbol: Grm1^tm1Crpl
• Name: glutamate receptor, metabotropic 1; targeted mutation 1, Francis Crepel
• MGI ID: MGI:1857986
• Synonyms: mGlu1-, mGluR1^-, mGluR1^lacz
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^tm1Crpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21644
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ neomycin cassette disrupted the exon encoding the seven-transmembrane-helix domain. Immunoblots of membrane preparations of cerebella from homozygous mutant mice showed no detectable native protein using antibodies against the C-terminal and N-terminal parts of the protein. (J:21644)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:21644 Conquet F, et al., Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1 [see comments]. Nature. 1994 Nov 17;372(6503):237-43
• All: 24 reference(s)