Grm1^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Grm1^tm1Stl
• Name: glutamate receptor, metabotropic 1; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:1857987
• Synonyms: mGluR1^-
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21086
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 2.1kb of the gene, including the 3' portion of exon 1 that encodes amino acids 1 - 233 of the protein. Northern blots of total RNA from cerebella of homozygous mutant mice showed no detectable transcripts of the targeted gene. Western blots of extracts of the cerebella of homozygous mutant mice showed no detectable protein. (J:21086)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:21086 Aiba A, et al., Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 1994 Oct 21;79(2):365-75
• All: 20 reference(s)