Grm2^tm1Nak
Targeted Allele Detail

Summary

• Symbol: Grm2^tm1Nak
• Name: glutamate receptor, metabotropic 2; targeted mutation 1, Shigetada Nakanishi
• MGI ID: MGI:1857988
• Synonyms: mGluR2 -
• Gene: Grm2 Location: Chr9:106521733-106533308 bp, - strand Genetic Position: Chr9, 57.98 cM
• Alliance: Grm2^tm1Nak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34606
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the translation initiation site and its downstream sequence in exon 2. Northern blot analysis and western blot analysis confirmed the absence of expression from this allele (data not shown). Immunocytochemical studies did not detect protein in hippocampal coronal sections of homozygous mutant adult mice. (J:34606)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm2 Mutation: 44 strains or lines available

References

• Original: J:34606 Yokoi M, et al., Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996 Aug 2;273(5275):645-7
• All: 22 reference(s)