Trp53^tm1Mlh
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Mlh
• Name: transformation related protein 53; targeted mutation 1, Martin L Hooper
• MGI ID: MGI:1857989
• Synonyms: p53-
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Mlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60008
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exons 2-6 with a neomycin cassette. (J:60008)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Mlh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:60008 Clarke AR, et al., Thymocyte apoptosis induced by p53-dependent and independent pathways [see comments]. Nature. 1993 Apr 29;362(6423):849-52
• All: 29 reference(s)