Pou3f4^tm1Cren
Targeted Allele Detail

Summary

• Symbol: Pou3f4^tm1Cren
• Name: POU domain, class 3, transcription factor 4; targeted mutation 1, Bryan Crenshaw III
• MGI ID: MGI:1857990
• Synonyms: Brn4-
• Gene: Pou3f4 Location: ChrX:109857886-109860813 bp, + strand Genetic Position: ChrX, 48.2 cM
• Alliance: Pou3f4^tm1Cren page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56294
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene and a PGK-neomycin resistance cassette replaced the entire intronless coding region and a small region of 3'-flanking sequences. (J:56294)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f4 Mutation: 4 strains or lines available

References

• Original: J:56294 Phippard D, et al., Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear. J Neurosci. 1999 Jul 15;19(14):5980-9
• All: 6 reference(s)