Pou3f4^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Pou3f4^tm1Tno
• Name: POU domain, class 3, transcription factor 4; targeted mutation 1, T Noda
• MGI ID: MGI:1857991
• Synonyms: Brn-4-
• Gene: Pou3f4 Location: ChrX:109857886-109860813 bp, + strand Genetic Position: ChrX, 48.2 cM
• Alliance: Pou3f4^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57298
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the coding region of this gene. Protein from homozygous mutant animals lacked DNA binding activity as determined by gel mobility shift assays. (J:57298)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f4 Mutation: 4 strains or lines available

References

• Original: J:57298 Minowa O, et al., Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness [see comments]. Science. 1999 Aug 27;285(5432):1408-11
• All: 5 reference(s)