Hoxa3^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa3^tm1Mrc
• Name: homeobox A3; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:1857992
• Synonyms: hox-1.5^-, Hoxa3-
• Gene: Hoxa3 Location: Chr6:52146042-52190316 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa3^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17753
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene was inserted into sequences encoding the homeobox domain. (J:17753)

Disease models

Expression

In Mice Carrying this Mutation:	101 assay results
In Structures Affected by this Mutation:	36 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa3 Mutation: 24 strains or lines available

References

• Original: J:17753 Chisaka O, et al., Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 [see comments]. Nature. 1991 Apr 11;350(6318):473-9
• All: 22 reference(s)