Pou3f1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou3f1^tm1Rsd
• Name: POU domain, class 3, transcription factor 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:1857994
• Synonyms: Oct-6^lacZ, Scip-LacZ, Tst-1-, Tst-1/Oct-6/SCIP-, tst-1/scip/oct-6
• Gene: Pou3f1 Location: Chr4:124551439-124554448 bp, + strand Genetic Position: Chr4, 57.86 cM
• Alliance: Pou3f1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34460
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ gene followed by a neomycin resistance cassette replaced sequences encoding the entire amino terminus and POU domain. No protein was detected in sections of cerebral cortex by immunohistochemical analysis. (J:34460)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f1 Mutation: 14 strains or lines available

References

• Original: J:34460 Bermingham JR Jr, et al., Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev. 1996 Jul 15;10(14):1751-62
• All: 7 reference(s)