Pou3f2^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou3f2^tm1Rsd
• Name: POU domain, class 3, transcription factor 2; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:1857996
• Synonyms: Brn-2-
• Gene: Pou3f2 Location: Chr4:22482780-22488366 bp, - strand Genetic Position: Chr4, 9.73 cM
• Alliance: Pou3f2^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30430
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding sequence of the gene. Immunohistochemical analysis demostrated an absence of expressed POU3F2 protein in the orbital cortex of homozygous mice. (J:30430)

Expression

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou3f2 Mutation: 19 strains or lines available

References

• Original: J:30430 Schonemann MD, et al., Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 1995 Dec 15;9(24):3122-35
• All: 3 reference(s)