Zp1^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Zp1^tm1Dean
• Name: zona pellucida glycoprotein 1; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:1857997
• Synonyms: Zp1^tm, Zp1^tm1Nih, Zp1^tm1Tra, Zp1^tm2Nih
• Gene: Zp1 Location: Chr19:10891660-10897965 bp, - strand Genetic Position: Chr19, 7.36 cM
• Alliance: Zp1^tm1Dean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56560
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1, intron 1, exon 2, inton 2 and part of exon 3 were replaced by a PGK-neomycin cassette. Homozygous mutant female mice were analyzed by Northern and Western blotting to establish that the mRNA and protein were not present in growing oocytes. (J:56560)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zp1 Mutation: 30 strains or lines available

References

• Original: J:56560 Rankin T, et al., Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. Development. 1999 Sep;126(17):3847-55
• All: 5 reference(s)