Pax2^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Pax2^tm1Mbu
• Name: paired box 2; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:1858000
• Synonyms: Pax2^-, Pax2^lacZ
• Gene: Pax2 Location: Chr19:44744484-44826310 bp, + strand Genetic Position: Chr19, 38.09 cM
• Alliance: Pax2^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63683
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of exon 2 encoding the paired box domain followed by the insertion of a LacZ reporter gene containing the 3'splice site of Pax5 exon 2. This allele is a derivative of Pax2^tm2Mbu created by cre-mediated deletion of a Pax5 cDNA which had been inserted into the Pax2 locus. (J:63683)

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax2 Mutation: 44 strains or lines available

References

• Original: J:63683 Bouchard M, et al., Functional equivalence of the transcription factors pax2 and pax5 in mouse development. Development. 2000 Sep;127(17):3703-13
• All: 11 reference(s)