Hoxa1^tm2Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm2Mrc
• Name: homeobox A1; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:1858002
• Synonyms: Hoxa1^Cla, Hoxa1/Hoxa2^-, Hoxa1/Hoxa2 double mutant
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58093
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Disruption by creating a frameshift mutation at the BglII site in the sequences encoding the homeobox. The BglII site was converted to a Cla1 site. (J:58093)

Expression

In Mice Carrying this Mutation:

54 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

Notes

This allele was made simultaneously with Hoxa2^tm1Mrc and is tightly linked to it.

References

• Original: J:58093 Barrow JR, et al., Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development. 1999 Nov;126(22):5011-26
• All: 2 reference(s)