Tal1^tm2Wehi
Targeted Allele Detail

Summary

• Symbol: Tal1^tm2Wehi
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 2, Walter and Eliza Hall, Institute of Medical Research
• MGI ID: MGI:1858004
• Synonyms: Scl^-, SCL-lacZ, SCL^lacZ
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm2Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50149
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a lacZ reporter gene into the 5' untranslated region of the gene. This mutation also deletes all coding sequences. (J:50149)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	53 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:50149 Elefanty AG, et al., Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ knock-in strategy. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11897-902
• All: 15 reference(s)