Ctnnb1^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1Mmt
• Name: catenin beta 1; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:1858008
• Synonyms: B-catenin^fl3, BcatGOF, beta-cat^act, beta-cat^c.a., beta-catenin^deltaex3, beta-catenin^lox-ex3, beta-catenin^loxEx3, beta-catenin/loxP(ex3), beta-cat^ex3, beta-cat^gof, beta-cat^loxEx3, Catnb^(ex3)fl, Catnb^(Flox3, Catnb^lox(ex3), Catnb^tm1Tak, Ctnnb1^ex3, Ctnnb1^(Ex3)fl, Ctnnb1^ex3(loxP), Ctnnb1^f(Ex3), Ctnnb1^fl(ex3), Ctnnb1^flx(ex3), Ctnnb1^iGOF, Ctnnb1^lox(ex3), Ctnnb^llox(ex3), Ctnnb^lox(ex3), GOF
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1Mmt page

Kidney agenesis in Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Hoxb7-cre)13Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58367
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of a PGK-neomycin resistance cassette introduced two loxP sites flanking exon 3 and the inserted cassette. Exon 3 contains phosphorylation target serine/threonine residues. Future deletion of exon 3 with cre recombinase would result in mRNA whose exons 2 and 4 are connected in frame. (J:58367)

Disease models

Expression

In Mice Carrying this Mutation:	332 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ctnnb1^tm1Mmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:58367 Harada N, et al., Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 1999 Nov 1;18(21):5931-42
• All: 537 reference(s)