Pik3cg^tm1Dwu
Targeted Allele Detail

Summary

• Symbol: Pik3cg^tm1Dwu
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 1, Dianqing Wu
• MGI ID: MGI:1858011
• Synonyms: p110gamma^-, PI3Kgamma^-
• Gene: Pik3cg Location: Chr12:32223472-32258658 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B
• Alliance: Pik3cg^tm1Dwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60348
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A part of the first exon and the entire second and third exons were replaced by a GFP gene, which was fused in-frame to the coding sequence of Pik3cg. GFP is expressed under the control of Pik3cg promoter elements in this allele. (J:60348)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3cg Mutation: 59 strains or lines available

References

• Original: J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
• All: 19 reference(s)