Msh6^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Msh6^tm1Rak
• Name: mutS homolog 6; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:1858014
• Synonyms: Msh6-
• Gene: Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh6^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44428
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted at codon 336 within exon 4 of the gene, resulting in a stop codon 21 nucleotides downstream. No transcript for the targeted gene was detected on Northern blots of RNA extracted from two double-targeted ES cell lines. No protein product for the targeted gene was detected on Western blots of protein extracted from two double-targeted ES cell lines. (J:44428)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh6^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh6 Mutation: 52 strains or lines available

References

• Original: J:44428 Edelmann W, et al., Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 1997 Nov 14;91(4):467-77
• All: 26 reference(s)