Csrp3^tm1Crni
Targeted Allele Detail

Summary

• Symbol: Csrp3^tm1Crni
• Name: cysteine and glycine-rich protein 3; targeted mutation 1, Pico Caroni
• MGI ID: MGI:1858015
• Synonyms: MLP-
• Gene: Csrp3 Location: Chr7:48480146-48497781 bp, - strand Genetic Position: Chr7, 31.11 cM, cytoband B3
• Alliance: Csrp3^tm1Crni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts derived from heart tissue confirmed that no stable protein was made from this allele. (J:38213)

Disease models

Expression

In Mice Carrying this Mutation:	44 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csrp3 Mutation: 15 strains or lines available

References

• Original: J:38213 Arber S, et al., MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 7;88(3):393-403
• All: 46 reference(s)