Csrp3^tm1Crni
Targeted Allele Detail

Summary

• Symbol: Csrp3^tm1Crni
• Name: cysteine and glycine-rich protein 3; targeted mutation 1, Pico Caroni
• MGI ID: MGI:1858015
• Synonyms: MLP-
• Gene: Csrp3 Location: Chr7:48480146-48497781 bp, - strand Genetic Position: Chr7, 31.11 cM, cytoband B3
• Alliance: Csrp3^tm1Crni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts derived from heart tissue confirmed that no stable protein was made from this allele. (J:38213)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1  Disease Model	Csrp3^tm1Crni/Csrp3^tm1Crni	Not Specified
cx2	Csrp3^tm1Crni/Csrp3^tm1Crni Prkca^tm1Jmk/Prkca^tm1Jmk	involves: 129
cx3	Csrp3^tm1Crni/Csrp3^tm1Crni Pln^tm1Egk/Pln^tm1Egk	involves: 129S2/SvPas * CF-1
cx4	Csrp3^tm1Crni/Csrp3^tm1Crni Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * SJL
cx5	Csrp3^tm1Crni/Csrp3^tm1Crni Tg(WTbeta2)4Wjk/0	Not Specified

Phenotypes:

Affected Systems	hm1	cx2	cx3	cx4	cx5
show or hide all annotated terms
cardiovascular system	√	√	√	√	√
cardiovascular system phenotype		N		N
abnormal intercalated disk morphology	√
increased myocardial fiber size	√
enlarged heart	√
increased heart weight	√
cardiac hypertrophy	√		√
dilated heart left ventricle	√	√			√
cardiac interstitial fibrosis	√			√
abnormal cardiovascular system physiology	√
dilated cardiomyopathy	√				√
decreased cardiac muscle contractility	√
decreased heart ventricle muscle contractility	√			√	√
increased cardiac muscle contractility			√
abnormal heart echocardiography feature	√
decreased heart rate			√
abnormal myocardial fiber physiology	√
congestive heart failure	√
cellular	√			√
cardiac interstitial fibrosis	√			√
abnormal actin cytoskeleton morphology	√
growth/size/body	√		√
enlarged heart	√
increased heart weight	√
cardiac hypertrophy	√		√
mortality/aging	√
postnatal lethality, incomplete penetrance	√
muscle	√		√	√	√
abnormal intercalated disk morphology	√
increased myocardial fiber size	√
dilated cardiomyopathy	√				√
decreased cardiac muscle contractility	√
decreased heart ventricle muscle contractility	√			√	√
increased cardiac muscle contractility			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	hm1
congestive heart failure IDs congestive heart failure       DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802 Close	√
dilated cardiomyopathy 1M IDs dilated cardiomyopathy 1M       DOID:0110449 ICD10CM:I42.0 OMIM:607482 Close	√

Expression

In Mice Carrying this Mutation:	44 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csrp3 Mutation: 15 strains or lines available

References

• Original: J:38213 Arber S, et al., MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 7;88(3):393-403
• All: 46 reference(s)