Ep300^tm1Dli
Targeted Allele Detail

Summary

• Symbol: Ep300^tm1Dli
• Name: E1A binding protein p300; targeted mutation 1, David Livingston
• MGI ID: MGI:1858020
• Synonyms: p300-
• Gene: Ep300 Location: Chr15:81470329-81536273 bp, + strand Genetic Position: Chr15, 38.16 cM
• Alliance: Ep300^tm1Dli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47301
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons encoding the first cys/his rich domain were replaced with a neomycin selection cassette. Western blot analysis on embryonic fibroblasts derived from homozygous E10.5 embryos demonstrated that no detectable protein was expressed. (J:47301)

Expression

In Mice Carrying this Mutation:	16 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ep300^tm1Dli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ep300 Mutation: 98 strains or lines available

References

• Original: J:47301 Yao TP, et al., Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998 May 1;93(3):361-72
• All: 8 reference(s)